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Israel launched airstrikes early Monday targeting central and western Iran in response to missile fire.
Iranian state television reported the sound of explosions being heard in Isfahan, Tabriz and Tehran, without immediately elaborating.
Iran closed the airspace around Tehran’s Imam Khomeini International Airport, the country’s main airfield, after the Israeli attack.
The attacks further strain efforts to reach a permanent ceasefire in the war between Iran and the United States.
Earlier, Iran launched missiles at Israel in the first such bombardment since a fragile ceasefire took effect in early April.
The exchange raised the possibility of a return to heavy fighting and complicating mediation efforts to end the war, which began when the U.S. and Israel attacked Iran on Feb. 28.
Israel’s military said it identified and intercepted missiles launched from Iran on Sunday, the first escalation of its kind since the fragile ceasefire came into effect in April. The attack follows Israeli strikes on Lebanon’s capital, Beirut, and comes as a ‘warning’ of further strikes if Israeli aggression continues, according to Iranian officials.